Posts Tagged ‘Perlane’

Collagen Injectables Discontinued as Popularity of Hyaluronic Acid Fillers Grows

Monday, July 12th, 2010

Radiesse before & after photosThe latest issue of Dermatology Times reports on the changing U.S. injectables market, given the news that most collagen fillers will be gone from the market at year’s end.

In January 2010, Allergan announced it would be discontinuing its collagen line of fillers— CosmoPlast, CosmoDerm and bovine products Zyderm and Zyplast—at the end of the year. The company halted production of the products last year, but manufactured sufficient inventory to meet estimated market demand through the end of 2010, according to Kelly Lao, manager of corporate communications.

In late 2009 Johnson & Johnson had announced that it was discontinuing its collagen filler Evolence.

“For my generation of dermatologists, collagen was the gold standard of fillers—this is what we were taught to use,” says Seth L. Matarasso, M.D., clinical professor of dermatology, University of California School of Medicine, San Francisco. “But the market is changing. Welcome to the brave new world of fillers.”

“The discontinuation of the sale of our collagen products … is in response to declined market interest … since the introduction of hyaluronic acid dermal fillers like Juvéderm have become more popular,” Ms. Lao says.

“There is an overwhelming popularity of the new kid on the block: the hyaluronic acids. They have been embraced universally, and suddenly collagens aren’t as popular,” says Dr. Matarasso.

The popularity of hyaluronic acid products, which includes Restylane, Perlane, Juvéderm, Radiesse and Sculptra, is due to factors that include:

  • Longer-lasting results
  • Appear to give a better fill
  • Some contain lidocaine for less painful injections

Upcoming improvements of hyaluronic acids, according to Dermatology Times, will provide more volume and contour-changing ability and the ability to fill deeper lines.

Read the full story, “Dermatologists prepare for departure of collagen from U.S. market,” online at Modern Medicine. (Before and after photos of Radiesse patient, courtesy of radiesse.com)

Injectables with Lidocaine Offer Pain Relief

Tuesday, June 22nd, 2010

Restylane logoOne of the latest advancements in the U.S. injectable fillers market is lidocaine-containing versions of popular hyaluronic acid fillers, reports the July 2010 issue of Cosmetic Surgery Times. Lidocaine is a local anesthetic that is injected directly into the body area and decreases pain by temporarily numbing that area, according to WebMD.

Three injectables won FDA approval in February 2010 for lidocaine versions in the U.S.:

The products performed similarly to their lidocaine-free predecessors in terms of safety and efficacy, according to Dr. Michael H. Gold, a clinical assistant professor of dermatology at Vanderbilt University School of Medicine and School of Nursing. Furthermore, “The incorporation of lidocaine has surely provided a higher comfort level for patients [in the clinical trials],” he says.

Dr. Gold adds that in his clinical experience when patients undergo an injection that includes even a small percentage of lidocaine, “Most patients say they barely feel the second stick. To me that is the home run of lidocaine in these fillers.”

In clinical studies by Medicis to support FDA approval, the addition of lidocaine to Restylane and Perlane substantially reduced pain experienced by patients, while demonstrating adverse event safety profiles similar to those of Restylane and Perlane, according to the Medicis release.

A method for doctors mixing lidocaine with Radiesse was cleared in July 2009. “Originally, I was against doctors mixing a lot of fillers because I was afraid of potential changes in the products themselves,” says Dr. Gold. But once the FDA clears these products, especially those premixed by manufacturers, “I’m pretty comfortable with it.”

Fillers with lidocaine among latest injectable advancements” is available online at Modern Medicine. Learn more about Restylane, Perlane, and Radiesse in Seattle.

Which Dermal Filler is Right For Me?

Thursday, July 9th, 2009

istock_000008969660xsmallRemember when the FDA first approved Collagen in 1982?  There was hope of looking more youthful, fear of potential allergic reactions, painful injections, and lots of swelling. Sometimes it took as long as a week before you finally looked normal.

Today we have a much wider range of safe, effective dermal fillers to choose from. They can be injected into the tiny lines around the eyes, the lines that have formed below the mouth, and the folds around the nose. They even can even fill-in areas that have lost volume, such as thinning lips and those deep furrows that develop between the eyebrows. Having any of these areas injected can take years off the face. It may even allow you to postpone cosmetic surgery, like a face-lift, for years.

All these new fillers can be used quickly, in an outpatient setting, and you’ll look great almost immediately.  Of course the downside is, fillers are temporary (lasting anywhere from a few months to a year), and some patients experience minor bruising and swelling.

The question many people want answered is: “Which one should I choose?”
The majority of the new fillers (not all) are made from Hyaluronic Acid, a natural substance found in the body. Below is a list and brief description of the dermal fillers that are available only from qualified practitioners:

  1. Restylane – a hyaluronic acid based filler touted as “the world’s best-selling dermal filler.” It is used for correcting moderate facial wrinkles and folds.
  2. Perlane – very similar to Restylane, it is designed primarily for treating deeper and more severe wrinkles and folds.
  3. Radiesse – this thick compound is made with (natural, biocompatible) calcium based microspheres in water based gel.
  4. Prevelle Silk – this hyaluronic acid gel filler is commonly used for lip augmentation treatments.
  5. Juvederm – Like Perlane, this popular filler is designed for treating deeper wrinkles and restoring volume to the face. It’s been called the “liquid facelift” treatment.
  6. Evolence – one of the newer injectables on the market, Evolence is made with purified porcine collagen. It helps create plumper cheeks and lips, and has a reputation for quick results and minimal bruising.

As with any cosmetic procedure, you should choose a doctor you trust and one who operates a practice that makes you feel comfortable. Remember, the use of injectables is an art, not just a science.  At our Seattle surgery office, we can help you make the right choice among the best dermal fillers available today.